He joined the Foreign Ministry in 1956. As ambassador he served at the United Nations at New York (1984-1986), Vienna (1986-1988) and London (1988-1997). During his tenure in Vienna, he was a member of the Board of Governors of the International Atomic Energy Agency (IAEA). Two years before, he was a representative of the Director General of the IAEA to the United Nations (1982-1983  ...

At the present, he is Chairman of the Board of a number of think tanks and academic institutions including the Egyptian Council for Foreign Affairs (a leading non governmental Think Tank), National Center for Middle East Studies, and Regional Information Technology Institute. He is also a member of the Board of the Nuclear Power Plants Authority.

He is Chairman of the Board of Trustees of a number of major philanthropic organizations namely; Sawiris Foundation for Social Development and Magdy Yacoub Foundation for Heart Research.

He also chaired two major international conferences; Review Conference of Nuclear Nonproliferation Treaty 1985 and Conference on the peaceful uses of the nuclear energy in 1987. He was a member of the U.N. Secretary-General’s Advisory Board on Disarmament Matters. He was a member of the UN Expert Group on Disarmament and Non-Proliferation Education (2001-2002).

Two of Dr Shaker’s major works are The Nuclear Non-Proliferation Treaty: Origin and Implementation 1959-1979 (3 volumes), New York: Oceana Publications, Dobbs Ferry, 1980. which was reproduced in an electronic copy issued by both the Egyptian Council for Foreign Affairs (ECFA) and James Martin Center for Nonproliferation Studies , California  in May 2010 ,and  The Evolving International Regime of Nuclear Non-Proliferation, Leiden/Boston : Martinus Nijhoff Publishers,2007 , The Hague Academy of International Law , Recueil des  Cours,  Vol. 321, 2006.